We’ve uncovered vulnerable components of Mtb metabolism: the aspartate pathway and the respiratory chain. In papers published in 2019 in Nature Communications and in 2017 in PNAS, we wrote about finding ways to eradicate Mtb persisters—the bacteria that resist conventional treatment. We’re now testing combinations of existing and novel enzyme inhibitors in vitro and in animal models.
I was a ski instructor in Switzerland and then in New Zealand during my days at university.
I have three children, ages 7, 9, and 11. They keep me very busy. But when I have time, I love running, biking, and skiing.
Currently, I am reading The ONE Thing: The Surprisingly Simple Truth Behind Extraordinary Results [by Gary W. Keller and Jay Papasan]. I also like to read biographies of great scientists, such as Albert Einstein and Craig Venter. And I just read The Remedy [by Thomas Goetz], about the quest to cure TB.